Bioequivalence and Bioavailability Forum

OT: TTT in bear [PK / PD]

posted by Helmut  – Vienna, Austria, 2013-07-18 22:28 (4710 d 05:00 ago) – Posting: # 11023
Views: 25,046

Dear Yung-jin,

❝ […] using log-linear regression with TTT rule as you suggest.

Incidentally I met one of the authors of the TTT-paper (Christian Scheerans) last month. He knew that you have implemented the method in bear after our discussions in the forum. He was very happy about that. He introduced R in his company (which was a Sisyphean task because his company is a very conservative German innovator). The only reason why he performed his simulations in Excel’s VBA was that he didn’t know R at that time. We (Martin, Jack, and I) have performed a comparison of different algos and confirmed that there are indeed differences in terms of bias and precision – but only when it comes to λ_z itself. Differences diminished when we com­pared AUC_∞. So we lost interest and never get it published.
After some discussion with Christian we are considering to extend the method for multi­com­part­ment profiles. Hopefully it will not go to the to-do-list and stay there forever…

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


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Complete thread:

• 1 compartment model with lag time jag009 2013-07-17 15:58 [PK / PD] 
  • solve for k01? Helmut 2013-07-17 16:08
    • solve for k01? jag009 2013-07-17 16:19
      • solve for k01? ElMaestro 2013-07-17 17:09
      • no closed form Helmut 2013-07-17 23:01
  • 1 compartment model with lag time yjlee168 2013-07-17 20:57
  • Package-free solution ElMaestro 2013-07-17 21:53
    • Package-free solution yjlee168 2013-07-17 22:11
      • Package-free solution ElMaestro 2013-07-17 22:27
        • Package-free solution yjlee168 2013-07-17 22:42
    • Package-free solution ElMaestro 2013-07-17 23:21
      • A new R-King was born d_labes 2013-07-18 08:45
        • Brent ElMaestro 2013-07-18 09:07
        • A new R-King was born yjlee168 2013-07-18 10:21
          • OT: TTT in bearHelmut 2013-07-18 20:28
            • OT: TTT in bear yjlee168 2013-07-18 22:17
              • OT: TTT subtleties d_labes 2013-07-19 09:47
                • OT: TTT subtleties yjlee168 2013-07-20 19:44
                  • OT: beyond TTT? Helmut 2013-07-21 00:08
                    • OT: beyond TTT? yjlee168 2013-07-22 13:45
                      • OT: keep TTT! Helmut 2013-07-22 14:21
                        • OT: keep TTT! yjlee168 2013-07-22 23:42
                          • OT: EOD (here) Helmut 2013-07-23 01:06
      • Package-free solution yjlee168 2013-07-18 10:27
        • Thank you guys! jag009 2013-07-18 16:37
          • Thank you guys! ElMaestro 2013-07-18 18:57
            • Thank you guys! jag009 2013-07-19 20:40