Bioequivalence and Bioavailability Forum • A new R-King was born

A new R-King was born [PK / PD]

posted by yjlee168 – Kaohsiung, Taiwan, 2013-07-18 12:21 (4710 d 13:01 ago) – Posting: # 11016
Views: 25,372

Dear Detlew,

❝ [...]

❝ What about the simple solution: "Log-linear regression of points after two times tmax (known as TTT rule), negative slope =k01"?

❝ Of course restricted to one-compartment model.

For John's question, it just happened that there was only one data point (t, C(t)) available. Log-linear regression with TTT rule seems not possible in this case. Of course, if John had a serial conc. vs. time data point, he can fit a one-compartment PK model directly to get all parameters simultaneously or using log-linear regression with TTT rule as you suggest.

—
All the best,
-- Yung-jin Lee
bear v2.9.6:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

Complete thread:

1 compartment model with lag time jag009 2013-07-17 15:58 [PK / PD]
- solve for k01? Helmut 2013-07-17 16:08
  - solve for k01? jag009 2013-07-17 16:19
    - solve for k01? ElMaestro 2013-07-17 17:09
    - no closed form Helmut 2013-07-17 23:01
- 1 compartment model with lag time yjlee168 2013-07-17 20:57
- Package-free solution ElMaestro 2013-07-17 21:53
  - Package-free solution yjlee168 2013-07-17 22:11
    - Package-free solution ElMaestro 2013-07-17 22:27
      - Package-free solution yjlee168 2013-07-17 22:42
  - Package-free solution ElMaestro 2013-07-17 23:21
    - A new R-King was born d_labes 2013-07-18 08:45
      - Brent ElMaestro 2013-07-18 09:07
      - A new R-King was bornyjlee168 2013-07-18 10:21
        
        OT: TTT in bear Helmut 2013-07-18 20:28
        
        OT: TTT in bear yjlee168 2013-07-18 22:17
        
        OT: TTT subtleties d_labes 2013-07-19 09:47
        
        OT: TTT subtleties yjlee168 2013-07-20 19:44
        
        OT: beyond TTT? Helmut 2013-07-21 00:08
        
        OT: beyond TTT? yjlee168 2013-07-22 13:45
        
        OT: keep TTT! Helmut 2013-07-22 14:21
        
        OT: keep TTT! yjlee168 2013-07-22 23:42
        
        OT: EOD (here) Helmut 2013-07-23 01:06
    - Package-free solution yjlee168 2013-07-18 10:27
      - Thank you guys! jag009 2013-07-18 16:37
        
        Thank you guys! ElMaestro 2013-07-18 18:57
        
        Thank you guys! jag009 2013-07-19 20:40