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Mei liaba Kokoschinsky!
(bajuvarian)
Respect!
Can you enlighten me what the reason was to choose
The range 0.001-100 is surely nearly exhaustive for k01 (elimination constant), but if elimination half life is >693.1472 hours ...
What about the simple solution: "Log-linear regression of points after two times tmax (known as TTT rule), negative slope =k01"?
Of course restricted to one-compartiment model.
@John:
A general criticism: I don't understand the problem. If we have concentration time points and fit a one-compartiment model we get all the parameters necessary for that model, including k01. I can't imagine situations where we have V, k10, t, tlag only but no k01.
(bajuvarian)
Respect!Can you enlighten me what the reason was to choose
method="Brent"?The range 0.001-100 is surely nearly exhaustive for k01 (elimination constant), but if elimination half life is >693.1472 hours ...
What about the simple solution: "Log-linear regression of points after two times tmax (known as TTT rule), negative slope =k01"?
Of course restricted to one-compartiment model.
@John:
A general criticism: I don't understand the problem. If we have concentration time points and fit a one-compartiment model we get all the parameters necessary for that model, including k01. I can't imagine situations where we have V, k10, t, tlag only but no k01.
—
Regards,
Detlew
Regards,
Detlew
Complete thread:
- 1 compartment model with lag time jag009 2013-07-17 15:58 [PK / PD]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- solve for k01? Helmut 2013-07-17 16:08
- solve for k01? jag009 2013-07-17 16:19
- solve for k01? ElMaestro 2013-07-17 17:09
- no closed form Helmut 2013-07-17 23:01
- solve for k01? jag009 2013-07-17 16:19
- 1 compartment model with lag time yjlee168 2013-07-17 20:57
- Package-free solution ElMaestro 2013-07-17 21:53
- Package-free solution yjlee168 2013-07-17 22:11
- Package-free solution ElMaestro 2013-07-17 22:27
- Package-free solution yjlee168 2013-07-17 22:42
- Package-free solution ElMaestro 2013-07-17 22:27
- Package-free solution ElMaestro 2013-07-17 23:21
- A new R-King was bornd_labes 2013-07-18 08:45
- Brent ElMaestro 2013-07-18 09:07
- A new R-King was born yjlee168 2013-07-18 10:21
- OT: TTT in bear Helmut 2013-07-18 20:28
- OT: TTT in bear yjlee168 2013-07-18 22:17
- OT: TTT subtleties d_labes 2013-07-19 09:47
- OT: TTT subtleties yjlee168 2013-07-20 19:44
- OT: beyond TTT? Helmut 2013-07-21 00:08
- OT: beyond TTT? yjlee168 2013-07-22 13:45
- OT: keep TTT! Helmut 2013-07-22 14:21
- OT: keep TTT! yjlee168 2013-07-22 23:42
- OT: EOD (here) Helmut 2013-07-23 01:06
- OT: keep TTT! yjlee168 2013-07-22 23:42
- OT: keep TTT! Helmut 2013-07-22 14:21
- OT: beyond TTT? yjlee168 2013-07-22 13:45
- OT: beyond TTT? Helmut 2013-07-21 00:08
- OT: TTT subtleties yjlee168 2013-07-20 19:44
- OT: TTT subtleties d_labes 2013-07-19 09:47
- OT: TTT in bear yjlee168 2013-07-18 22:17
- OT: TTT in bear Helmut 2013-07-18 20:28
- Package-free solution yjlee168 2013-07-18 10:27
- Thank you guys! jag009 2013-07-18 16:37
- Thank you guys! ElMaestro 2013-07-18 18:57
- Thank you guys! jag009 2013-07-19 20:40
- Thank you guys! ElMaestro 2013-07-18 18:57
- Thank you guys! jag009 2013-07-18 16:37
- A new R-King was bornd_labes 2013-07-18 08:45
- Package-free solution yjlee168 2013-07-17 22:11
- solve for k01? Helmut 2013-07-17 16:08
Ing. Helmut Schütz