Bioequivalence and Bioavailability Forum • Package-free solution

Package-free solution [PK / PD]

posted by ElMaestro – Denmark, 2013-07-18 01:21 (4711 d 01:01 ago) – Posting: # 11012
Views: 25,159

And here's for those who prefer a minimum of typing:

Conc=function(D, K01, K10, V, t, tlag)

{

 C = ((D*K01)/(V*(K01-K10))) * (exp(-K10*(t-tlag)) - exp(-K01*(t-tlag)))

 return(C)

}



Cx=Conc(100, 1.67, 0.213, 10, 6, 0.5)



Objective.Func=function(K01)

{

  return(abs (Cx-Conc(100, K01, 0.213,10,6,0.5)))

}



optim(c(0.1), Objective.Func, method="Brent", lower=0.001, upper=100.0)

—
Pass or fail!
ElMaestro

Complete thread:

1 compartment model with lag time jag009 2013-07-17 15:58 [PK / PD]
- solve for k01? Helmut 2013-07-17 16:08
  - solve for k01? jag009 2013-07-17 16:19
    - solve for k01? ElMaestro 2013-07-17 17:09
    - no closed form Helmut 2013-07-17 23:01
- 1 compartment model with lag time yjlee168 2013-07-17 20:57
- Package-free solution ElMaestro 2013-07-17 21:53
  - Package-free solution yjlee168 2013-07-17 22:11
    - Package-free solution ElMaestro 2013-07-17 22:27
      - Package-free solution yjlee168 2013-07-17 22:42
  - Package-free solutionElMaestro 2013-07-17 23:21
    - A new R-King was born d_labes 2013-07-18 08:45
      - Brent ElMaestro 2013-07-18 09:07
      - A new R-King was born yjlee168 2013-07-18 10:21
        
        OT: TTT in bear Helmut 2013-07-18 20:28
        
        OT: TTT in bear yjlee168 2013-07-18 22:17
        
        OT: TTT subtleties d_labes 2013-07-19 09:47
        
        OT: TTT subtleties yjlee168 2013-07-20 19:44
        
        OT: beyond TTT? Helmut 2013-07-21 00:08
        
        OT: beyond TTT? yjlee168 2013-07-22 13:45
        
        OT: keep TTT! Helmut 2013-07-22 14:21
        
        OT: keep TTT! yjlee168 2013-07-22 23:42
        
        OT: EOD (here) Helmut 2013-07-23 01:06
    - Package-free solution yjlee168 2013-07-18 10:27
      - Thank you guys! jag009 2013-07-18 16:37
        
        Thank you guys! ElMaestro 2013-07-18 18:57
        
        Thank you guys! jag009 2013-07-19 20:40