Bioequivalence and Bioavailability Forum

Dear Hiren
I think in your example there is a misunderstanding: if you administer 100mg of Drug X and the bioavailability is 1% than according to your example 0.8mg went into the systemic circulation via GIT and 0.2mg are absorbed sublingually. In such a case emesis will definetly matter.
BTW how do you exactly know how much of a drug is absorbed sublingually or in the GIT? This strongly depends on your formulation. All you see in the BE study is the systemic bioavailability. Oral bioavailability does not mean sublingual bioavalability! Oral bioavalability just defines the portion of a drug available after oral (including sublingual) administration in contrast to e.g. rectal or transdermal application.
I hope this helps.
Kind regards
Dan