AUC∞ = lousy metric [NCA / SHAM]

posted by Helmut Homepage – Vienna, Austria, 2013-06-20 19:29 (3934 d 21:17 ago) – Posting: # 10841
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Hi John,

❝ Not trying to play genius but isn't that obvious since AUCinf is based on AUCt and a component which is based on extrapolation and in turn dependent on regression?


Yes & no. The variability is higher because it depends on Clast which is expected to be the most variable data point of the profile. That’s trivial. More interesting is that AUC might also be biased especially for two-compartment PK and caused by not always ‘catching’ the true λz in the area of LLOQ.

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