Bioequivalence and Bioavailability Forum

Main page Policy/Terms of Use Abbreviations Latest Posts

 Log in |  Register |  Search

Back to the forum  2018-06-25 17:40 CEST (UTC+2h)

Three-way crossover BABE Studies [Design Issues]

posted by acfalcao - 2007-09-16 22:34  - Posting: # 1082
Views: 9,675

Dear All

My name is Amilcar Falcão and I am professor at the University of Coimbra, Portugal. I am looking for help regarding the execution and interpretation of three-way cross-over bioequivalence trials (for academic purposes).

I would like to have an example (explicit) where a three-way crossover study is appropriately analysed. Namely, I would like to know what kind of ANOVA should be performed and how the 90%CI should be calculated for the different combinations of study formulations (i.e. A vs B and A vs C). Perhaps this is a naive question, but in fact I am trying to look for it in literature and I have seen different approaches always without the adopted statistical pathway. Therefore, I would like to be sure regarding the correct way to deal with.

I strongly appreciate if you could help me about this matter.

Thank you for your attention.

Best regards; :-)

Amílcar Falcão
Laboratory of Pharmacology
Faculty of Pharmacy
University of Coimbra
Coimbra - Portugal

Complete thread:

Back to the forum Activity
 Mix view
Bioequivalence and Bioavailability Forum |  Admin contact
18,428 posts in 3,913 threads, 1,176 registered users;
online 29 (1 registered, 28 guests [including 20 identified bots]).

Lack of clarity is always a sign of dishonesty.    Celia Green

BEBAC Ing. Helmut Schütz