Lin-up/log-down trapezoidal example [NCA / SHAM]
Dear Yung-jin,
I checked one study of bimodal release formulations. Imbalanced, n=15. I evaluated AUCt based on the linear trapezoidal and the lin-up/log-down method. Then I introduced a failure of the centrifuge resulting in a complete loss of 12 h samples in the second period. Let’s see:
❝ […] is there any special consideration when using lin-up/log-down trapezoidal rule to calculate AUCs if there is more than one absorption peak?
I checked one study of bimodal release formulations. Imbalanced, n=15. I evaluated AUCt based on the linear trapezoidal and the lin-up/log-down method. Then I introduced a failure of the centrifuge resulting in a complete loss of 12 h samples in the second period. Let’s see:
PE 90% CI %CVintra %CVinter
complete, linear 99.89 95.23–104.78 7.38 33.75
complete, lin-up/log-down 99.78 95.10–104.69 7.42 33.40
incomplete, linear 100.08 95.64–104.72 7.00 33.84
incomplete, lin-up/log-down 99.93 95.37–104.72 7.23 33.39
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- handling of missing data gracehung 2013-05-20 07:35
- Lin-up/log-down trapezoidal avoids most trouble Helmut 2013-05-20 14:22
- Lin-up/log-down trapezoidal avoids most trouble yjlee168 2013-05-22 08:25
- Multiple peaks: fallback to linear trapezoidal Helmut 2013-05-22 20:25
- Multiple peaks: fallback to linear trapezoidal yjlee168 2013-05-22 21:57
- No interpolation Helmut 2013-05-22 23:25
- No interpolation yjlee168 2013-05-23 11:43
- Spaghetti & other pasta Helmut 2013-05-23 15:15
- Spaghetti & other pasta yjlee168 2013-05-23 20:47
- Spaghetti & other pasta Helmut 2013-05-23 21:29
- Spaghetti & other pasta yjlee168 2013-05-23 22:46
- Spaghetti & other pasta Helmut 2013-05-24 01:24
- Spaghetti & other pasta yjlee168 2013-05-24 09:17
- Spaghetti & other pasta Helmut 2013-05-24 01:24
- Spaghetti & other pasta yjlee168 2013-05-23 22:46
- Spaghetti & other pasta Helmut 2013-05-23 21:29
- Spaghetti & other pasta yjlee168 2013-05-23 20:47
- Spaghetti & other pasta Helmut 2013-05-23 15:15
- No interpolation Ken Peh 2013-05-30 19:55
- Different algos! Helmut 2013-05-30 22:38
- Different algos! Ken Peh 2013-06-03 17:52
- Calculate what? Helmut 2013-06-03 18:11
- Different algos! Ken Peh 2013-06-03 17:52
- Different algos! Helmut 2013-05-30 22:38
- No interpolation yjlee168 2013-05-23 11:43
- No interpolation Helmut 2013-05-22 23:25
- Multiple peaks: fallback to linear trapezoidal yjlee168 2013-05-22 21:57
- Lin-up/log-down trapezoidal exampleHelmut 2013-05-25 15:09
- Lin-up/log-down trapezoidal example yjlee168 2013-05-25 19:45
- Multiple peaks: fallback to linear trapezoidal Helmut 2013-05-22 20:25
- Lin-up/log-down trapezoidal avoids most trouble yjlee168 2013-05-22 08:25
- handling of missing data Ohlbe 2013-05-20 21:45
- Sorry Helmut 2013-05-21 13:53
- Sorry gracehung 2013-05-23 01:06
- Uncertain time point Helmut 2013-05-23 01:35
- Sorry gracehung 2013-05-23 01:06
- Sorry Helmut 2013-05-21 13:53
- Lin-up/log-down trapezoidal avoids most trouble Helmut 2013-05-20 14:22