Spaghetti & other pasta [NCA / SHAM]

posted by yjlee168 Homepage – Kaohsiung, Taiwan, 2013-05-24 11:17 (3962 d 01:02 ago) – Posting: # 10638
Views: 17,073

Dear Helmut,

❝ ❝ Actually, lin-up/log-down method is still a kind of data smoothing approach.


❝ No, it isn’t.


You are right. It isn't. Sorry about this.

❝ [...] I gave the interpolation/imputation formulas only as a hint what might happen if we need an intermediate data point. If we want to calculate the area in the interval [t2, t2] no interpolation, smoothing, whatsoever is done. Both methods are straightforward:


I see. Thank you for your detailed explanation once again.

linear: AUCt1→t2=0.5(t2–t1)(C2+C1)

linlog: AUCt1→t2=(t2–t1)(C2–C1)/log(C2/C1)


All the best,
-- Yung-jin Lee
bear v2.9.1:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
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