Spaghetti & other pasta [NCA / SHAM]
Dear Helmut,
You are right. It isn't. Sorry about this.
I see. Thank you for your detailed explanation once again.
❝ ❝ Actually, lin-up/log-down method is still a kind of data smoothing approach.
❝
❝ No, it isn’t.
You are right. It isn't. Sorry about this.
❝ [...] I gave the interpolation/imputation formulas only as a hint what might happen if we need an intermediate data point. If we want to calculate the area in the interval [t2, t2] no interpolation, smoothing, whatsoever is done. Both methods are straightforward:
I see. Thank you for your detailed explanation once again.
❝ linear: AUCt1→t2=0.5(t2–t1)(C2+C1)
❝ linlog: AUCt1→t2=(t2–t1)(C2–C1)/log(C2/C1)
—
All the best,
-- Yung-jin Lee
bear v2.9.1:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here
All the best,
-- Yung-jin Lee
bear v2.9.1:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here
Complete thread:
- handling of missing data gracehung 2013-05-20 07:35
- Lin-up/log-down trapezoidal avoids most trouble Helmut 2013-05-20 14:22
- Lin-up/log-down trapezoidal avoids most trouble yjlee168 2013-05-22 08:25
- Multiple peaks: fallback to linear trapezoidal Helmut 2013-05-22 20:25
- Multiple peaks: fallback to linear trapezoidal yjlee168 2013-05-22 21:57
- No interpolation Helmut 2013-05-22 23:25
- No interpolation yjlee168 2013-05-23 11:43
- Spaghetti & other pasta Helmut 2013-05-23 15:15
- Spaghetti & other pasta yjlee168 2013-05-23 20:47
- Spaghetti & other pasta Helmut 2013-05-23 21:29
- Spaghetti & other pasta yjlee168 2013-05-23 22:46
- Spaghetti & other pasta Helmut 2013-05-24 01:24
- Spaghetti & other pastayjlee168 2013-05-24 09:17
- Spaghetti & other pasta Helmut 2013-05-24 01:24
- Spaghetti & other pasta yjlee168 2013-05-23 22:46
- Spaghetti & other pasta Helmut 2013-05-23 21:29
- Spaghetti & other pasta yjlee168 2013-05-23 20:47
- Spaghetti & other pasta Helmut 2013-05-23 15:15
- No interpolation Ken Peh 2013-05-30 19:55
- Different algos! Helmut 2013-05-30 22:38
- Different algos! Ken Peh 2013-06-03 17:52
- Calculate what? Helmut 2013-06-03 18:11
- Different algos! Ken Peh 2013-06-03 17:52
- Different algos! Helmut 2013-05-30 22:38
- No interpolation yjlee168 2013-05-23 11:43
- No interpolation Helmut 2013-05-22 23:25
- Multiple peaks: fallback to linear trapezoidal yjlee168 2013-05-22 21:57
- Lin-up/log-down trapezoidal example Helmut 2013-05-25 15:09
- Lin-up/log-down trapezoidal example yjlee168 2013-05-25 19:45
- Multiple peaks: fallback to linear trapezoidal Helmut 2013-05-22 20:25
- Lin-up/log-down trapezoidal avoids most trouble yjlee168 2013-05-22 08:25
- handling of missing data Ohlbe 2013-05-20 21:45
- Sorry Helmut 2013-05-21 13:53
- Sorry gracehung 2013-05-23 01:06
- Uncertain time point Helmut 2013-05-23 01:35
- Sorry gracehung 2013-05-23 01:06
- Sorry Helmut 2013-05-21 13:53
- Lin-up/log-down trapezoidal avoids most trouble Helmut 2013-05-20 14:22