What is the question? [Study Assessment]
Boys!
From my vacation: What is your problem
?
This is some pooled value of the intra-subject variances of T and R 1).
So don't expect to get a value comparable to s2wR!
1) R.J. McNally
Tests for Individual and Population Bioequivalence Using 3-Period Crossover Designs
online here.
gives in the context of appropriate intra-subject contrasts (aka progesterone guidance):
where s2I is the variance of the difference T-R used for calculating the 90% CI, s2D is the subject-by-formulation interaction, s2wT and s2wR are the intra-subject variabilities of Test or Reference, respectively.
Since you didn't provide me s2wT try it by your own assuming s2D=0 which in many cases could be reasonably assumed for the partial replicate design.
Remember our discussion on specifying compound symmetry in the FDA Proc Mixed code.
From my vacation: What is your problem
?CVfromCI() gives you the CV for the difference T vs. R.This is some pooled value of the intra-subject variances of T and R 1).
So don't expect to get a value comparable to s2wR!
1) R.J. McNally
Tests for Individual and Population Bioequivalence Using 3-Period Crossover Designs
online here.
gives in the context of appropriate intra-subject contrasts (aka progesterone guidance):
s2I=(s2D + s2wT + s2wR/2)where s2I is the variance of the difference T-R used for calculating the 90% CI, s2D is the subject-by-formulation interaction, s2wT and s2wR are the intra-subject variabilities of Test or Reference, respectively.
Since you didn't provide me s2wT try it by your own assuming s2D=0 which in many cases could be reasonably assumed for the partial replicate design.
Remember our discussion on specifying compound symmetry in the FDA Proc Mixed code.
—
Regards,
Detlew
Regards,
Detlew
Complete thread:
- Interesting Data from HVD study jag009 2013-05-16 22:15 [Study Assessment]
- Detlew? Helmut 2013-05-17 02:03
- What is the question?d_labes 2013-05-20 17:28
- Answer: forget the partial replicate! Helmut 2013-05-20 18:17
- What is the question? jag009 2013-06-04 16:04
- What is the question?d_labes 2013-05-20 17:28
- Detlew? Helmut 2013-05-17 02:03
