What is the question? [Study As­sess­ment]

posted by d_labes  – Berlin, Germany, 2013-05-20 19:28 (4774 d 04:21 ago) – Posting: # 10606
Views: 6,621

Boys!

From my vacation: What is your problem :confused:?

CVfromCI() gives you the CV for the difference T vs. R.
This is some pooled value of the intra-subject variances of T and R 1).
So don't expect to get a value comparable to s2wR!


1) R.J. McNally
Tests for Individual and Population Bioequivalence Using 3-Period Crossover Designs
online here.
gives in the context of appropriate intra-subject contrasts (aka progesterone guidance):
s2I=(s2D + s2wT + s2wR/2)
where s2I is the variance of the difference T-R used for calculating the 90% CI, s2D is the subject-by-formulation interaction, s2wT and s2wR are the intra-subject variabilities of Test or Reference, respectively.

Since you didn't provide me s2wT try it by your own assuming s2D=0 which in many cases could be reasonably assumed for the partial replicate design.
Remember our discussion on specifying compound symmetry in the FDA Proc Mixed code.

Regards,

Detlew

Complete thread:

UA Flag
Activity
 Admin contact
23,654 posts in 4,992 threads, 1,571 registered users;
126 visitors (0 registered, 126 guests [including 13 identified bots]).
Forum time: 23:50 CEST (Europe/Vienna)

The idea is to try and give all the information to help others
to judge the value of your contribution;
not just the information that leads to judgment
in one particular direction or another.    Richard Feynman

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5