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RegisterConfidence Interval for Transformed data Unbalanced study [General Statistics]
Dear,
I am looking for help on estimation of 90% confidence interval for log transformed data of AUC (0-inf) for a bioequivalence study. This study involved two-way crossover, two-period, two-sequence design with a total of 33 subjects completing the study. Each sequence had Period I TR=16 and RT=17, and in Period II TR=17 and RT=16; thus, total of 33 completed the study.
In order to estimate the 90% confidence interval, can some one help me with the formula and a worked out example for the ease of understanding. OR Guide me to a site where this can be found.
I believe least-squares mean estimate for each formulation needs to be used to form the difference, together with the standard error. However, in lack of exact formula i am seeking the help of experts out there.
Thanks in advance for the help.
USFDA_EMEA
Edit: Category changed. [Helmut]
I am looking for help on estimation of 90% confidence interval for log transformed data of AUC (0-inf) for a bioequivalence study. This study involved two-way crossover, two-period, two-sequence design with a total of 33 subjects completing the study. Each sequence had Period I TR=16 and RT=17, and in Period II TR=17 and RT=16; thus, total of 33 completed the study.
In order to estimate the 90% confidence interval, can some one help me with the formula and a worked out example for the ease of understanding. OR Guide me to a site where this can be found.
I believe least-squares mean estimate for each formulation needs to be used to form the difference, together with the standard error. However, in lack of exact formula i am seeking the help of experts out there.
Thanks in advance for the help.
USFDA_EMEA
Edit: Category changed. [Helmut]
Complete thread:
- Confidence Interval for Transformed data Unbalanced studyusfda_emea 2007-03-06 14:39 [General Statistics]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- CI for Transformed data Unbalanced study Helmut 2007-03-06 16:46
- CI for Transformed data Unbalanced study drshiv 2007-03-06 18:49
- CI for Transformed data Unbalanced study usfda_emea 2007-03-07 06:21
- CI for Transformed data Unbalanced study Helmut 2007-03-07 12:04
- CI for Transformed data Unbalanced study usfda_emea 2007-03-07 12:34
- CI for Transformed data Unbalanced study Ohlbe 2014-07-30 15:04
- LSM limbo Helmut 2014-07-31 02:54
- LSM limbo Ohlbe 2014-07-31 09:47
- 90% CI limbo VStus 2017-03-01 14:07
- RSABE ⇒ ABEL Helmut 2017-03-03 13:34
- RSABE ⇒ ABEL VStus 2017-03-03 15:31
- s2wR != mse, FDA != EMA d_labes 2017-03-04 14:49
- s2wR != mse, FDA != EMA ElMaestro 2017-03-04 19:13
- s2wR from ISC in FDA approach d_labes 2017-03-05 12:18
- s2wR from ISC in FDA approach ElMaestro 2017-03-05 13:50
- s2wR from ISC in FDA approach d_labes 2017-03-05 12:18
- s2wR != mse, FDA != EMA VStus 2017-03-04 21:41
- s2wR != mse, FDA != EMA Helmut 2017-03-06 13:40
- s2wR != mse, FDA != EMA ElMaestro 2017-03-04 19:13
- s2wR != mse, FDA != EMA d_labes 2017-03-04 14:49
- RSABE ⇒ ABEL VStus 2017-03-03 15:31
- RSABE ⇒ ABEL Helmut 2017-03-03 13:34
- LSM limbo Helmut 2014-07-31 02:54
- CI for Transformed data Unbalanced study Helmut 2007-03-07 12:04
- CI for Transformed data Unbalanced study Helmut 2007-03-06 16:46
Ing. Helmut Schütz