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RegisterPharmacokinetic Models vs. NCA [Design Issues]
Hi Venu!
Not only 2x2 cross-overs, but also 4x4, 6x3, replicate designs, parallel groups,...
Additional to NCA you are free to perform any type of evaluation you want.
No.
For details (especially why compartmental models are not used in BA/BE) see Helmut's post.
❝ In BA/BE studies, why only 2x2 crossover design noncompartmental models are used in most of the pilot and pivotal studies?
Not only 2x2 cross-overs, but also 4x4, 6x3, replicate designs, parallel groups,...
❝ When can you use the compartmental models in the BA/BE stuides?
Additional to NCA you are free to perform any type of evaluation you want.
❝ Does the use of these compartmental models depend on the nature of the generic drugs.
No.
❝ Please if you could provide more information in detail regarding the questions mentioned above. 
For details (especially why compartmental models are not used in BA/BE) see Helmut's post.
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Regards, Jaime
Regards, Jaime
Complete thread:
- Pharmacokinetic Models venu 2007-02-14 05:00
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Pharmacokinetic Models vs. NCAJaime_R 2007-02-14 11:44
- Pharmacokinetic Models vs. NCA venu 2007-02-21 04:54
- Pharmacokinetic Models drshiv 2007-02-25 15:08
- Pharmacokinetic Models vs. NCAJaime_R 2007-02-14 11:44
Ing. Helmut Schütz