Bioequivalence and Bioavailability Forum • Example

Example [Regulatives / Guidelines]

posted by Helmut – Vienna, Austria, 2017-05-02 14:35 (2985 d 04:30 ago) – Posting: # 17291
Views: 32,603

Hi ElMaestro,

❝ Could you tell how you got your F-test denominator? I am sure you are right, but I don't know where it came from. For an interaction of a between- and within-factor I think the rule of thumb (which is also a wee bit hard to define :-D ) is to test against the within, which in this case would be the model residual.

Yep. Below an example of model 1 in Phoenix/WinNonlin. Two groups (n=24 each), all effects fixed.

Partial Sum of Squares

            Hypothesis DF        SS        MS   F_stat  P_value

---------------------------------------------------------------

                 Group  1 0.0131109 0.0131109 1.0385149 0.31374

              Sequence  1 0.0058638 0.0058638 0.4644731 0.49914

             Treatment  1 0.0011965 0.0011965 0.0947752 0.75964

        Group*Sequence  1 0.0108734 0.0108734 0.8612869 0.35844

          Group*Period  2 0.0160976 0.0080488 0.6375490 0.53340

       Group*Treatment  1 0.0131109 0.0131109 1.0385149 0.31374

Group*Sequence*Subject 44 0.555484  0.0126246 1         0.50000

                 Error 44 0.555484  0.0126246



Partial Tests of Model Effects

            Hypothesis Numer_DF Denom_DF  F_stat   P_value

----------------------------------------------------------

                 Group        1       44 1.0385149 0.31374

              Sequence        1       44 0.4644731 0.49914

             Treatment        1       44 0.0947752 0.75964

        Group*Sequence        1       44 0.8612869 0.35844

          Group*Period        2       44 0.6375490 0.53340

       Group*Treatment        1       44 1.0385149 0.31374

Group*Sequence*Subject       44       44 1         0.50000

N: Σn_G = 48
G: 2
Numerator DF: G – 1 = 1
Denominator DF: N - 2G = 44
F: 0.0131109/0.0126246 = 1.0385149

round(pf(1.0385149, 1, 44, lower.tail=FALSE), 5)

# [1] 0.31374

✔

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Helmut Schütz

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Complete thread:

Russian «Экспертами» and their hobby Helmut 2017-04-29 00:46
- Low power of Group-by-Treatment interaction mittyri 2017-04-29 22:57
  - Let’s forget the Group-by-Treatment interaction, please! Helmut 2017-04-30 13:54
    - Let’s forget the Group-by-Treatment interaction, please! ElMaestro 2017-05-01 16:19
      - Some answers Helmut 2017-05-02 01:10
        
        Some answers ElMaestro 2017-05-02 09:04
        
        ExampleHelmut 2017-05-02 12:35
        
        Sensitivity of term? mittyri 2017-05-02 18:29
        
        Simulations Helmut 2017-05-05 14:38
        
        loosing specificity due to low sensitivity mittyri 2017-05-08 23:28
        
        loosing specificity due to low sensitivity Helmut 2017-05-09 00:55
        
        Loss in power Helmut 2017-05-06 17:31
        Interval between groups Helmut 2017-05-08 19:02
        
        IMP handling mittyri 2017-05-08 23:40
        
        IMP handling Helmut 2017-05-09 01:08
        
        Loss in power Helmut 2017-05-14 17:22
      - No convergence in JMP and Phoenix WinNonlin Helmut 2017-05-25 15:26
        
        Ouch?!??? ElMaestro 2017-05-25 16:24
- Russian «Экспертами» and their hobby Artem Gusev 2017-05-02 16:13
  - be careful with mixed models mittyri 2017-05-02 17:53
    - be careful with mixed models Artem Gusev 2017-05-03 11:02
  - p-value(s) in model 2 Helmut 2017-05-05 14:48
- Russian «Экспертами» following the EEU GLs Helmut 2017-05-24 20:17
  - Russian «Экспертами» following the EEU GLs Beholder 2017-05-24 22:37
    - Penalty for carelessness mittyri 2017-05-25 08:52
    - Russian «Экспертами» following the EEU GLs Beholder 2017-05-25 10:43
  - Russian «Экспертами» following the EEU GLs Mikalai 2018-01-04 10:43
    - Belarus = member of the EEU Helmut 2018-01-04 13:08
      - Belarus = member of the EEU Mikalai 2018-01-04 19:49
      - Trying your model for EEU mittyri 2018-01-04 22:04
        
        Trying your model for EEU Helmut 2018-01-05 00:06
        
        help us to stop it, please... Astea 2018-01-10 12:09
        
        help us to stop it, please... Beholder 2018-01-10 12:49
        regulators convinced by science? d_labes 2018-01-10 15:15
        
        regulators convinced by science? Beholder 2018-01-10 17:14
        
        Чёрт побери! d_labes 2018-01-10 18:53
        
        regulators convinced by science? Astea 2018-01-10 19:10
        
        Excuse me d_labes 2018-01-10 20:18
        
        Excuse me Astea 2018-01-10 20:38