Bioequivalence and Bioavailability Forum

❝ I didn't get the reason of splitting by replicate.

❝ I would follow one of the methods explained here by Detlew. Note that exact tests are preferred due to ties.

Hi Mittyri,

Sorry for delay in reply.

I have splitted in two parts, as i already explained, Tmax of test and tmax of reference is not a generated data, it ia one of the protocol defined time points, So logically we have to compare tmax of test to reference. If i take the average of T&T and R&R, the resulted value will not give a clearity about Tmax of formulations.

Second i case of ties, logically we can prove the similarity in terms of Tmax for test and Referecne. But statistically, it will give significant p-value, which means there is a difference. This diffecenre is due to non-ties values. So how to justify. Actually, we can not say there is a significant difference in tmax.

Thanks

---

Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]