Upper confidence bound and confidence interval of RSABE [RSABE / ABEL]

posted by WinnieH – Sweden, 2023-03-21 11:58 (837 d 15:28 ago) – Posting: # 23507
Views: 2,272

Hi all,

By reading this nice lecture: Page 23- 25, I get more clear idea about the 95% upper confidence bound concept. Many thanks!

Here I have one following question (maybe very naive), I was wondering that why we need rearrange the SABE model
ln(0.8)*sigmaW/sigma0 <= muT-muR <= ln(1.25)*sigmaW/sigma0
to the linear form
(muT-muR)2-(ln(1.25)*sigmaW/sigma0)2<=0
and then calculate the 95% CI from the linear form? What will happen if we use the regular unscaled BE way to calculate 90% CI of muT-muR and compare with the scaled BE limits?

Thank you very much!

Best regards,
Winnie

Complete thread:

UA Flag
Activity
 Admin contact
23,427 posts in 4,929 threads, 1,677 registered users;
30 visitors (0 registered, 30 guests [including 12 identified bots]).
Forum time: 04:26 CEST (Europe/Vienna)

Many people tend to look at programming styles and languages like religions:
if you belong to one, you cannot belong to others.
But this analogy is another fallacy.    Niklaus Wirth

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5