Bioequivalence and Bioavailability Forum • fixed swr

fixed swr [RSABE / ABEL]

posted by martin – Austria, 2013-03-29 16:07 (4482 d 01:57 ago) – Posting: # 10311
Views: 25,459

Hi Helmut !

Yep; your are totally right (should have done my homework first ;-)

). what about defining the extent of scaling after interim analysis of the first stage data (CV estimated in 1st stage) within a group-sequential adaptive design?

Drawback: BUT what if the CV at interim is smaller than 0.3 ... :confused:

best regards

martin

Complete thread:

‘alpha’ of scaled ABE? d_labes 2013-03-15 15:56
- ‘alpha’ of scaled ABE? Helmut 2013-03-15 17:27
  - ’alpha’ of scaled ABE: design d_labes 2013-03-16 20:10
    - N=24, 48 d_labes 2013-03-18 08:11
      - adaptive design without adjustment martin 2013-03-25 20:47
        
        α adjustment? Helmut 2013-03-26 15:21
        
        iteratively adjusted alpha martin 2013-03-26 16:19
        
        throw away our sample size tables? Helmut 2013-03-26 18:02
        
        if real martin 2013-03-26 19:44
        
        regulators don’t care? Helmut 2013-03-26 21:18
        
        adjusting α Helmut 2013-08-11 16:19
        
        missing letter apapanas 2024-10-31 06:02
        
        PowerTOST: sampleN.scABEL.ad() Helmut 2024-10-31 08:41
        
        PowerTOST: sampleN.scABEL.ad() apapanas 2024-11-08 10:48
        
        Molins et al. (2017) Helmut 2024-11-08 14:34
        
        target α in sim’s? Helmut 2013-03-27 15:38
        
        target α in sim’s? martin 2013-03-27 16:36
        
        If it is real: results Helmut 2013-03-28 23:20
        
        having alpha martin 2013-03-28 15:08
        
        fixed swr Helmut 2013-03-28 23:34
        
        fixed swrmartin 2013-03-29 15:07
        
        Yes but no but yes but no but… Helmut 2013-03-29 16:10