Potvin C consequences [Two-Stage / GS Designs]

posted by ElMaestro  – Denmark, 2022-06-27 19:13 (1449 d 03:37 ago) – Posting: # 23095
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Hi mittyri,

❝ So T1E (OK, maximum type I error) depends on the CV, isn't it?

❝ Or may be I misunderstood your point and we should not verify T1E during estimation process since we are assuming that the framework was stated as acceptable in the Protocol?


Depends on the CV, but does not depend on the estimated CV. And that's a very significant difference. You never know anything other than your estimates, i.e. the knowledge that is generated as results of your trial do not determine the (maximum) type I error.
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Pass or fail!
ElMaestro

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