Bioequivalence and Bioavailability Forum • T1E after 1st stage in Power2Stage

T1E after 1st stage in Power2Stage [Two-Stage / GS Designs]

posted by mittyri – Russia, 2022-06-24 23:05 (1452 d 12:34 ago) – Posting: # 23083
Views: 8,001

Hi ElMaestro,

❝ Mixing up the terms alpha and T1E is a real danger for 2-stage approaches, since in "normal" trials they are one and the same.

yep, I should reformulate: T1E for the adaptive study finished after 1st stage due to BE goal reached (or some other reason to stop)

—
Kind regards,
Mittyri

Complete thread:

T1E after 1st stage in Power2Stage mittyri 2022-06-24 13:43
- T1E after 1st stage in TSDs Helmut 2022-06-24 14:33
  - T1E after 1st stage in TSDs mittyri 2022-06-24 21:12
    - T1E after 1st stage in TSDs Helmut 2022-06-25 14:07
      - Potvin C consequences mittyri 2022-06-25 23:29
        
        Potvin C consequences ElMaestro 2022-06-26 09:11
        
        Potvin C consequences mittyri 2022-06-27 13:45
        
        Potvin C consequences Helmut 2022-06-27 14:49
        
        from Potvin C to Inverse Normal mittyri 2022-06-27 17:13
        
        From Potvin C to Inverse Normal: history (and outlook?) Helmut 2022-06-27 18:54
        
        Potvin C consequences ElMaestro 2022-06-27 17:13
        
        true CV ≠ observed CV mittyri 2022-06-27 17:22
- T1E after 1st stage in Power2Stage ElMaestro 2022-06-24 18:25
  - T1E after 1st stage in Power2Stagemittyri 2022-06-24 21:05
    - T1E after 1st stage in Power2Stage ElMaestro 2022-06-24 22:55

Admin contact
23,654 posts in 4,992 threads, 1,571 registered users;
136 visitors (0 registered, 136 guests [including 25 identified bots]).
Forum time: 11:39 CEST (Europe/Vienna)

Always listen to experts.
They’ll tell you what can’t be done and why.
Then do it. Robert A. Heinlein

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC

Ing. Helmut Schütz