Bioequivalence and Bioavailability Forum

Puzzle: Estimation of half life [Surveys]

posted by Helmut  – Vienna, Austria, 2011-07-26 18:03 (5436 d 08:38 ago) – Posting: # 7226
Views: 15,607

Dear all!

From a consultant’s diary:

• Study performed in 2011 | IR formulation | very common drug | large CRO.
  
• Of course, the report stated “correlation coefficient mandatory >0.95” and “PK parameters were calculated in a blinded manner”…
  
• Maybe the pharmacokineticist was blind?
  
• PK followed a 2- or 3-compartment model in all subjects.
  
• No plots of the estimation of λ_z in the report.
  I generated the one above by trial and error to match tabulated half lives.
  
• No table showing how many and which data points were used.

What do you think?

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


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Complete thread:

• Puzzle: Estimation of half lifeHelmut 2011-07-26 16:03 
  • Puzzle: Estimation of half life ElMaestro 2011-07-27 10:58
    • Puzzle: Estimation of half life Helmut 2011-07-27 15:10
  • Puzzle: Estimation of half life d_labes 2011-07-28 08:44
    • Puzzle: Estimation of half life Helmut 2011-07-28 11:38
  • Puzzle: Estimation of half life ElMaestro 2011-07-28 10:24
    • Puzzle: Estimation of half life Helmut 2011-07-28 11:53
      • 100% QC? ElMaestro 2011-07-28 16:38
        • No idea Helmut 2011-07-28 17:03