Bioequivalence and Bioavailability Forum • gender specific generics?

gender specific generics? [Surveys]

posted by Dr_Dan – Germany, 2011-03-11 16:24 (5570 d 11:07 ago) – Posting: # 6751
Views: 10,626

Dear ElMaestro
dear all
I just evaluated the second study with the same compound/dose/nearly identical formulation.
Evaluation with the whole study population => bioequivalent
Subgroups:
males => AUC bioequivalent
females => AUC bioequivalent
90% confidence intervals for AUC for males and females have no overlap
(99-121 vs 83-95)
90% confidence intervals for Cmax for males and females congruent.
Is this just a statistical artefact?
Looking forward to your reply
Kind regards
Dan

—
Kind regards and have a nice day
Dr_Dan

Complete thread:

gender specific generics? Dr_Dan 2011-02-17 10:34
- gender specific generics? ElMaestro 2011-02-17 13:54
  - gender specific generics? Dr_Dan 2011-02-17 15:09
    - gender specific generics? ElMaestro 2011-02-17 15:44
      - gender specific generics?Dr_Dan 2011-03-11 15:24
        
        gender specific generics? Helmut 2011-03-11 15:32
        gender specific generics? ElMaestro 2011-03-11 16:37
        
        gender specific generics? Dr_Dan 2011-03-14 09:20
        
        Formulation-by-gender interaction? d_labes 2011-03-14 08:32