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Hi HS,
I am not the one to answer this interesting question, and I hope there will be some input from more qualified people.
Clearly I would use option 1b; if pre-dose is not the lowest in practice then we are looking at data that do not reflect reality but random fluctuations or mixups (unless, of course, the body is capable of synthesizing the drug or metabolite under investigation which is generally not the case for the majority of substances). And in fact Cmin,ss is to some people like me a misnomer; should be called Ctrough, with trough being defined as predose.
My 0.02 euros.
EM.
I am not the one to answer this interesting question, and I hope there will be some input from more qualified people.
Clearly I would use option 1b; if pre-dose is not the lowest in practice then we are looking at data that do not reflect reality but random fluctuations or mixups (unless, of course, the body is capable of synthesizing the drug or metabolite under investigation which is generally not the case for the majority of substances). And in fact Cmin,ss is to some people like me a misnomer; should be called Ctrough, with trough being defined as predose.
My 0.02 euros.
EM.
Complete thread:
- Cmin (EU) Helmut 2009-12-21 13:08
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Cmin (EU)ElMaestro 2009-12-22 14:17
- Terminology issues Helmut 2009-12-22 14:30
- Philostics ElMaestro 2009-12-27 00:47
- Philostics Helmut 2009-12-27 02:01
- Philostics ElMaestro 2009-12-27 13:28
- Philostics Helmut 2009-12-27 15:07
- Philostics ElMaestro 2009-12-28 02:46
- Philostics Helmut 2009-12-27 15:07
- Philostics ElMaestro 2009-12-27 13:28
- Philostics Helmut 2009-12-27 02:01
- Philostics ElMaestro 2009-12-27 00:47
- Terminology issues Helmut 2009-12-22 14:30
- Cmin (EU) d_labes 2010-01-04 10:45
- Repeated profiles Helmut 2010-01-04 13:53
- Cmin-value <LLOQ beman 2010-01-04 15:43
- Cmin-value <LLOQ Helmut 2010-01-04 16:34
- Cmin (EU)ElMaestro 2009-12-22 14:17
Ing. Helmut Schütz