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Registerbimodal absorption process? [PK / PD]
Dear all!
I just hit upon some really strange concentration-time profiles following SC administration: It looks like that concentrations follow a bi-modal absorption process with a mixture of zero-order and first-order absorption, where first order peak (clearly smaller) follows zero-order peak with a time-lag. Elimination looks like one-compartmental first order.
Do you know some literature/references where such a pharmacokinetic model is mentioned/described? Is it straight-forward to apply NCA or should i try to fit a "fancy" model?
Thanks a lot!
Alex
I just hit upon some really strange concentration-time profiles following SC administration: It looks like that concentrations follow a bi-modal absorption process with a mixture of zero-order and first-order absorption, where first order peak (clearly smaller) follows zero-order peak with a time-lag. Elimination looks like one-compartmental first order.
Do you know some literature/references where such a pharmacokinetic model is mentioned/described? Is it straight-forward to apply NCA or should i try to fit a "fancy" model?
Thanks a lot!
Alex
Complete thread:
- bimodal absorption process?Alex 2012-11-29 11:45
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- SC: mixed absoption Helmut 2012-11-29 14:23
- solution or suspension? Dr_Dan 2012-11-29 15:27
- solution or suspension? Alex 2012-11-30 08:44
- t½ (el.) in flop flop PK Helmut 2012-11-30 13:08
- solution or suspension? Alex 2012-11-30 08:44
Ing. Helmut Schütz