Bioequivalence and Bioavailability Forum • Factors Affecting Tmax

Factors Affecting Tmax [PK / PD]

posted by jag009 – NJ, 2012-05-04 01:00 (4813 d 16:42 ago) – Posting: # 8510
Views: 11,082

Hi everyone,

Assuming a drug which is highly soluble and permable (BCS 1). The IR %release In-vitro is NLT 85% by 15-30 mins, yet the in-vivo Tmax is 4 hours (that's the minimum, some subjects have 10. Average is 6). Half-life of drug is 20-30 hours and it's ~ 85% protein bound. What factors contribute to ths long Tmax? Tissue distribution is obvious.

Thanks

John

Complete thread:

Factors Affecting Tmaxjag009 2012-05-03 23:00
- Factors Affecting Tmax luvblooms 2012-05-04 06:04
  - Factors Affecting Tmax Chiku 2012-08-01 14:29
- Factors Affecting Tmax Chiku 2012-08-01 14:26
  - Memantine? Helmut 2012-08-01 15:09
    - Memantine? Chiku 2012-08-02 07:50
      - Memantine! Helmut 2012-08-02 19:57
        
        Memantine! Chiku 2012-08-03 13:06