Antiemetic Drugs can change PK profiles [PK / PD]

posted by mittyri  – Russia, 2016-12-27 18:15 (3116 d 21:17 ago) – Posting: # 16887
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Dear anky1212,

This question is not so easy to answer.
The best way to control vomiting and nausea is peripheral dopamine receptor blocker like Domperidone or central blocker like Metoclopramide (also blocks central effects, but they aren't needed here, right?).
By the way using these drugs you can change gastric/enteric motility and also bioavailability of drugs of interest.
Please consider to review this paper
I didn't find any data regarding active antiemetic therapy in BEQ studies for Stalevo.

Maybe more experienced colleagues have more information...

Kind regards,
Mittyri

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