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RegisterQuantification of S-amlodipine [PK / PD]
I agree with you Nobody.
If the analytical response of S-amlodipine present in racemic compound is the same of isolate enantiomer using chiral method, I can determinate the purity.
But, in my case, I do not have a chiral method available in bio-analysis. Then, I keep my doubt...can I use Amlodipine (racemic) instead of S-amlodipine (enantiomeric form) as analitical standard? Both standard are available on the market, but I can not aquire the pure enantiomere in short time.
What are the guaranties of my correct quantification of S-Amlodipine in plasma with a method that do not make any difference between R and S enantiomeres present in analitical reference standard?
If the analytical response of S-amlodipine present in racemic compound is the same of isolate enantiomer using chiral method, I can determinate the purity.
But, in my case, I do not have a chiral method available in bio-analysis. Then, I keep my doubt...can I use Amlodipine (racemic) instead of S-amlodipine (enantiomeric form) as analitical standard? Both standard are available on the market, but I can not aquire the pure enantiomere in short time.
What are the guaranties of my correct quantification of S-Amlodipine in plasma with a method that do not make any difference between R and S enantiomeres present in analitical reference standard?
Complete thread:
- Linear Pharmacokinetics of Levamlodipine Mauricio Sampaio 2015-10-07 00:24
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Linear Pharmacokinetics of Levamlodipine Mauricio Sampaio 2016-06-03 22:33
- Quantification of S-amlodipine Mauricio Sampaio 2016-06-06 16:19
- Quantification of S-amlodipine Helmut 2016-06-06 20:23
- Quantification of S-amlodipine nobody 2016-06-07 08:29
- Quantification of S-amlodipineMauricio Sampaio 2016-06-07 18:35
- Quantification of S-amlodipine Helmut 2016-06-08 01:32
- Quantification of S-amlodipine Mauricio Sampaio 2016-06-09 21:48
- Quantification of S-amlodipine Helmut 2016-06-08 01:32
- Quantification of S-amlodipineMauricio Sampaio 2016-06-07 18:35
- Quantification of S-amlodipine nobody 2016-06-07 08:29
- Quantification of S-amlodipine Helmut 2016-06-06 20:23
- Quantification of S-amlodipine Mauricio Sampaio 2016-06-06 16:19
- Linear Pharmacokinetics of Levamlodipine martin 2016-06-09 15:22
- Linear Pharmacokinetics of Levamlodipine Mauricio Sampaio 2016-06-09 22:03
- Linear Pharmacokinetics of Levamlodipine martin 2016-06-12 21:48
- Linear Pharmacokinetics of Levamlodipine Mauricio Sampaio 2016-06-09 22:03
- Linear Pharmacokinetics of Levamlodipine Mauricio Sampaio 2016-06-03 22:33
Ing. Helmut Schütz