Bioequivalence and Bioavailability Forum

Dear friends!

I am involved in the planing phase of a repeated dose TK study (pre-clincal) in which drug is administered by infusion and I am wondering whether there is a conflict regarding zero-order absorption processes and linear kinetics IF one can assume a constant infusion interval (for a given dose range)?

I want to know if it is valid to play around with different simulated scenarios (different doses, different dosing intervals, ...) on the assumption of linear kinetics AND a constant infusion interval...

Thanks a lot, as always...
Alex