Log in
RegisterBizarre discussion… [PK / PD]
Dear Helmut,
this is (and was) totally clear to me. But was that comparison not meaningful at all? I have correctly guessed that the drug was a pro-drug, so this is the additional information yielded from this comparison. And msnaimar (and we all) has the experience from previous studies that in the vast majority of cases the value of AUC > value of Cmax with the units specified, so he/she suspected an error.
I also always check the aberrant results (aberrant from other values obtained in the same experiment or aberrant from other studies), so it was correct that msnaimar asked his question. The ratio Cmax/AUC > 1 (with the units specified) says something about the shape and width of the concentration-time curve, i.e. the curve is sharpe and narrow.
Of course, if we would have also the values of tmax and t1/2 we could say more about the shape of the PK curve, but you can make some conclusions based only on Cmax and AUC.
With kind regards,
Jan
this is (and was) totally clear to me. But was that comparison not meaningful at all? I have correctly guessed that the drug was a pro-drug, so this is the additional information yielded from this comparison. And msnaimar (and we all) has the experience from previous studies that in the vast majority of cases the value of AUC > value of Cmax with the units specified, so he/she suspected an error.
I also always check the aberrant results (aberrant from other values obtained in the same experiment or aberrant from other studies), so it was correct that msnaimar asked his question. The ratio Cmax/AUC > 1 (with the units specified) says something about the shape and width of the concentration-time curve, i.e. the curve is sharpe and narrow.
Of course, if we would have also the values of tmax and t1/2 we could say more about the shape of the PK curve, but you can make some conclusions based only on Cmax and AUC.
With kind regards,
Jan
Complete thread:
- Cmax value higher than AUC msmnainar 2015-02-16 13:41
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Cmax value higher than AUC ElMaestro 2015-02-16 13:46
- Cmax value higher than AUC msmnainar 2015-02-16 13:51
- Cmax value higher than AUC ElMaestro 2015-02-16 14:01
- Cmax value higher than AUC nobody 2015-02-16 14:23
- Cmax value higher than AUC Dr_Dan 2015-02-17 08:11
- Cmax value higher than AUC nobody 2015-02-17 09:38
- Cmax value higher than AUC janmacek 2015-02-17 10:41
- Cmax value higher than AUC nobody 2015-02-17 11:19
- Cmax value higher than AUC msmnainar 2015-02-17 11:36
- Magic ElMaestrolophystic RoadShow ElMaestro 2015-02-17 14:56
- Magic ElMaestrolophystic RoadShow janmacek 2015-02-17 16:02
- Magic ElMaestrolophystic RoadShow nobody 2015-02-17 16:32
- Bizarre discussion… Helmut 2015-02-17 17:06
- Bizarre discussion…janmacek 2015-02-17 17:42
- Magic ElMaestrolophystic RoadShow janmacek 2015-02-17 16:02
- Cmax value higher than AUC nobody 2015-02-17 11:19
- Cmax value higher than AUC janmacek 2015-02-17 10:41
- Cmax value higher than AUC Dr_Dan 2015-02-17 18:53
- Cmax value higher than AUC nobody 2015-02-17 20:16
- Cmax value higher than AUC nobody 2015-02-17 09:38
- Cmax value higher than AUC ElMaestro 2015-02-16 14:01
- Cmax value higher than AUC msmnainar 2015-02-16 13:51
- Cmax value higher than AUC ElMaestro 2015-02-16 13:46
Ing. Helmut Schütz