Bioequivalence and Bioavailability Forum

Bizarre discussion… [PK / PD]

posted by Helmut  – Vienna, Austria, 2015-02-17 18:06 (3796 d 14:05 ago) – Posting: # 14442
Views: 15,129

Dear Jan,

❝ […] the discussion was simply about comparison of two numbers, 1000 and 730.

OK, but is such a comparison meaningful at all? No way. We have values, which consist of two parts: a number and a unit.
IMHO, comparing numbers whilst ignoring units doesn’t make any [sic] sense.
Some physicians notoriously “forget” units. When they tell me “The patient has a value of 37!” I use to reply “37 what? Cats? That’s a lot if he lives in a small apartment.”

There is a nice thing in physics called unit equa­tion. Let’s go back to msmnainar’s example of C_max 1,000 ng/mL and AUC 730 h×ng/mL. What do we mean in com­mon language when we say sum­fink is smaller than another? We calculate a dif­fe­rence (two apples are less than three) or a ratio (hey, T/R). In the former case the unit equation would no work at all and in the latter the result for AUC/C_max would be 0.73 h. Gimme a break! Please don’t tell me that two apples are less than three oranges.

Another example: The orthodromic distance from Moscow to Vladi­vostoc is 6,434 km. Makes quite a walk. If we switch units – do you think that 0.0000000002085pc are shorter?

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


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Complete thread:

• Cmax value higher than AUC msmnainar 2015-02-16 13:41 
  • Cmax value higher than AUC ElMaestro 2015-02-16 13:46
    • Cmax value higher than AUC msmnainar 2015-02-16 13:51
      • Cmax value higher than AUC ElMaestro 2015-02-16 14:01
        • Cmax value higher than AUC nobody 2015-02-16 14:23
        • Cmax value higher than AUC Dr_Dan 2015-02-17 08:11
          • Cmax value higher than AUC nobody 2015-02-17 09:38
            • Cmax value higher than AUC janmacek 2015-02-17 10:41
              • Cmax value higher than AUC nobody 2015-02-17 11:19
                • Cmax value higher than AUC msmnainar 2015-02-17 11:36
              • Magic ElMaestrolophystic Road­Show ElMaestro 2015-02-17 14:56
                • Magic ElMaestrolophystic Road­Show janmacek 2015-02-17 16:02
                  • Magic ElMaestrolophystic Road­Show nobody 2015-02-17 16:32
                  • Bizarre discussion…Helmut 2015-02-17 17:06
                    • Bizarre discussion… janmacek 2015-02-17 17:42
          • Cmax value higher than AUC Dr_Dan 2015-02-17 18:53
            • Cmax value higher than AUC nobody 2015-02-17 20:16