Bioequivalence and Bioavailability Forum • Cmax value higher than AUC

Cmax value higher than AUC [PK / PD]

posted by Dr_Dan – Germany, 2015-02-17 09:11 (3792 d 17:42 ago) – Posting: # 14434
Views: 15,071

Hi ElMaestro

❝ It doesn't make sense. At least not to me.

❝ AUCt is a concentration integrated over time, Cmax is a concentration.

You are right that msnaimar can not directly compare two different units on the one hand but on the other hand the question is reasonable. Is it possible that Cmax > AUCt? IMHO not. Cmax just represents one point of the curve (o.k. it is the highest) but AUC represents all points under the curve i.e. Cmax + all the rest and therefore the value for AUC must be >> as the value for Cmax provided that you use the same dimension for concentration (in our case ng/ml), right?
Please explain if I am completely wrong
Kind regards
Dr_Dan

—
Kind regards and have a nice day
Dr_Dan

Complete thread:

Cmax value higher than AUC msmnainar 2015-02-16 13:41
- Cmax value higher than AUC ElMaestro 2015-02-16 13:46
  - Cmax value higher than AUC msmnainar 2015-02-16 13:51
    - Cmax value higher than AUC ElMaestro 2015-02-16 14:01
      - Cmax value higher than AUC nobody 2015-02-16 14:23
      - Cmax value higher than AUCDr_Dan 2015-02-17 08:11
        
        Cmax value higher than AUC nobody 2015-02-17 09:38
        
        Cmax value higher than AUC janmacek 2015-02-17 10:41
        
        Cmax value higher than AUC nobody 2015-02-17 11:19
        
        Cmax value higher than AUC msmnainar 2015-02-17 11:36
        
        Magic ElMaestrolophystic RoadShow ElMaestro 2015-02-17 14:56
        
        Magic ElMaestrolophystic RoadShow janmacek 2015-02-17 16:02
        
        Magic ElMaestrolophystic RoadShow nobody 2015-02-17 16:32
        Bizarre discussion… Helmut 2015-02-17 17:06
        
        Bizarre discussion… janmacek 2015-02-17 17:42
        
        Cmax value higher than AUC Dr_Dan 2015-02-17 18:53
        
        Cmax value higher than AUC nobody 2015-02-17 20:16