Bioequivalence and Bioavailability Forum • Kel or λz?

Kel or λz? [PK / PD]

posted by luvblooms – India, 2014-12-29 06:51 (3836 d 19:50 ago) – Posting: # 14194
Views: 11,431
(edited on 2014-12-29 09:19)

❝ Hi Helmut

Just want to add something here

❝ If you are dealing with an oral dose it is practically impossible to claim enterohepatic recycling.

There are few examples where hepatic recirculation is very much obivious in oral dose as well. For e.g.Ezetemibe where the amount of ezetimibe recycled into the central compartment was estimated to be approximately 17% to 20% of the total amount absorbed, independent of the volume of distribution

❝ A second peak may also be the result of transfer for the stomach to the duodenum, a food effect (increased hepatic blood flow), etc. Only if you see a second peak after an iv dose you have strong hints.

One more reason sould be differential solubility and absorption across GIT (Diclofenac). The best way to that whether HR is there or not is to use IV dose if no prior published information is available.

—
~A happy Soul~

Complete thread:

enterohepatic recycling, how to calculate Kel? Astea 2014-12-28 12:40
- Kel or λz? Helmut 2014-12-28 13:56
  - Kel or λz? Astea 2014-12-28 14:42
    - Kel or λz? Helmut 2014-12-28 15:34
      - Kel or λz? Astea 2014-12-28 17:48
        
        Kel or λz? mittyri 2014-12-28 20:25
        
        Kel or λz? Astea 2014-12-28 21:21
        
        Kel or λz? Helmut 2014-12-29 02:58
        
        Kel or λz? Astea 2014-12-29 10:38
        
        TOST Helmut 2014-12-29 14:14
        
        PowerTOST d_labes 2014-12-31 13:41
  - Kel or λz?luvblooms 2014-12-29 05:51
    - Kel or λz? nobody 2014-12-29 21:54
      - Kel or λz? luvblooms 2014-12-30 05:25