Bioequivalence and Bioavailability Forum • Kel or λz?

Kel or λz? [PK / PD]

posted by Astea – Russia, 2014-12-28 15:42 (3837 d 15:18 ago) – Posting: # 14183
Views: 11,568

Thanks a lot for your answer!
I shall explain: we deal with the standard BE study: mycophenolic acid orally. The achieved curves have multi-peak form: there is a second small peak, that could be reffered as enterohepatic recycling (known in literature for MPA). So the question is how to determine the half life of such drug? Do we need to use the second terminal part of the curve?
And additional silly question: three samples in the log/linear decline can include Cmax-sample or there should be three samples after Tmax? And if the latest of them is zero is the regression line correct?

Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post! [Helmut]

—
"Being in minority, even a minority of one, did not make you mad"

Complete thread:

enterohepatic recycling, how to calculate Kel? Astea 2014-12-28 12:40
- Kel or λz? Helmut 2014-12-28 13:56
  - Kel or λz?Astea 2014-12-28 14:42
    - Kel or λz? Helmut 2014-12-28 15:34
      - Kel or λz? Astea 2014-12-28 17:48
        
        Kel or λz? mittyri 2014-12-28 20:25
        
        Kel or λz? Astea 2014-12-28 21:21
        
        Kel or λz? Helmut 2014-12-29 02:58
        
        Kel or λz? Astea 2014-12-29 10:38
        
        TOST Helmut 2014-12-29 14:14
        
        PowerTOST d_labes 2014-12-31 13:41
  - Kel or λz? luvblooms 2014-12-29 05:51
    - Kel or λz? nobody 2014-12-29 21:54
      - Kel or λz? luvblooms 2014-12-30 05:25