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Registerfactors affecting Tmax [PK / PD]
Hi all,
Question, maybe elementary but need some hints...
What factors can lead to a long Tmax like 7-8 hours? Lets say the drug 1) is BCS Class 1, 2) dissolution is completed within 1 hour (NLT 80% in 30 mins)?
1) Site specific/region specific absorption such as drug absorption does not take place until the lower part of the small intestine?
3) Saturable carrier transport?
2) Highly protein bound properties?
Thanks
John
Question, maybe elementary but need some hints...
What factors can lead to a long Tmax like 7-8 hours? Lets say the drug 1) is BCS Class 1, 2) dissolution is completed within 1 hour (NLT 80% in 30 mins)?
1) Site specific/region specific absorption such as drug absorption does not take place until the lower part of the small intestine?
3) Saturable carrier transport?
2) Highly protein bound properties?
Thanks
John
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Ing. Helmut Schütz