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RegisterPK basics… [PK / PD]
posted by Helmut 
– Vienna, Austria, 2014-07-01 17:10 (4026 d 11:37 ago) – Posting: # 13192
Views: 6,123
Hi Pravin,
Absorption is independent from distribution/elimination. What we “see” in the very late part of the profile reflects the slowest rate-constant of the drug’s PK (not necessarily elimination). Your example is typical for a controlled release formulation. Once we cross the Rubicon of flip-flop PK (ka ≤ kel) what you call “half life” likely describes absorption – not elimination.
❝ Dear Sir,
▲▲ Not interested in opinions of female members of the Forum?
❝ Please explain me that how it is possible that half life is early or less that its Tmax. For one drug half life is 5hrs and Tmax is 13hrs.
Absorption is independent from distribution/elimination. What we “see” in the very late part of the profile reflects the slowest rate-constant of the drug’s PK (not necessarily elimination). Your example is typical for a controlled release formulation. Once we cross the Rubicon of flip-flop PK (ka ≤ kel) what you call “half life” likely describes absorption – not elimination.
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Helmut Schütz
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Half life and Tmax pravin17 2014-07-01 14:29
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Half life and Tmax ElMaestro 2014-07-01 15:04
- PK basics…Helmut 2014-07-01 15:10
- PK basics… pravin17 2014-07-11 08:28
Ing. Helmut Schütz