Bioequivalence and Bioavailability Forum • WNL ⇒ PHX/WNL

WNL ⇒ PHX/WNL [PK / PD]

posted by Helmut – Vienna, Austria, 2014-01-23 17:29 (4184 d 06:46 ago) – Posting: # 12246
Views: 7,019

Hi John,

❝ Have you tried using the graphic editor in Phoenix to do this? How do you factor in the bile emptying interval (or the "lagtime" before the bile is released into the gut and subsquently the reabsorption from the GI")?

Nope. I only once translated a two-sequence absorption model (MPH ) from my classical WNL-code to PHX. Took me days… I’m too busy right now to give you the details – I suggest to ask at Pharsight’s Extranet in the meantime. It would be useful if you could upload a project containing data of one profile.

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Complete thread:

modeling profiles with enterohepatic recirculation jag009 2014-01-20 23:25
- modeling profiles with enterohepatic recirculation luvblooms 2014-01-21 11:47
- modeling profiles with enterohepatic recirculation Helmut 2014-01-21 13:00
  - modeling profiles with enterohepatic recirculation jag009 2014-01-21 16:18
  - modeling profiles with enterohepatic recirculation jag009 2014-01-23 16:18
    - WNL ⇒ PHX/WNLHelmut 2014-01-23 16:29
      - WNL ⇒ PHX/WNL jag009 2014-01-23 20:09
      - WNL ⇒ PHX/WNL SDavis 2014-01-24 14:21