Bioequivalence and Bioavailability Forum

modeling profiles with enterohepatic recirculation [PK / PD]

posted by jag009 – NJ, 2014-01-23 17:18 (4185 d 22:03 ago) – Posting: # 12245
Views: 7,063

Hi Helmut,

❝ Gabrielsson/Weiner (all editions) contains “PK40” in classical WinNonlin-code. I modified it a while ago for po dosing. In my experience the biggest obstacle was finding constraints for the gall bladder emptying time if the reabsorbed fraction was not pronounced. More an art than science.

Question... Have you tried using the graphic editor in Phoenix to do this? How do you factor in the bile emptying interval (or the "lagtime" before the bile is released into the gut and subsquently the reabsorption from the GI")?

Thanks

John

Complete thread:

modeling profiles with enterohepatic recirculation jag009 2014-01-20 23:25
- modeling profiles with enterohepatic recirculation luvblooms 2014-01-21 11:47
- modeling profiles with enterohepatic recirculation Helmut 2014-01-21 13:00
  - modeling profiles with enterohepatic recirculation jag009 2014-01-21 16:18
  - modeling profiles with enterohepatic recirculationjag009 2014-01-23 16:18
    - WNL ⇒ PHX/WNL Helmut 2014-01-23 16:29
      - WNL ⇒ PHX/WNL jag009 2014-01-23 20:09
      - WNL ⇒ PHX/WNL SDavis 2014-01-24 14:21

modeling profiles with enterohepatic re­circulation [PK / PD]

Complete thread:

modeling profiles with enterohepatic recirculation [PK / PD]