Bioequivalence and Bioavailability Forum • Parallel bears meeting at random in infinity

Parallel bears meeting at random in infinity [🇷 for BE/BA]

posted by yjlee168 – Kaohsiung, Taiwan, 2010-04-23 01:09 (5891 d 16:56 ago) – Posting: # 5189
Views: 67,863

Dear d_labes & ElMaestro,

❝ Call:

❝ lm(formula = lnAUC0t ~ drug + subj, data = TotalData)

Is this possible caused by unbalanced parallel data set? I changed the built-in dataset in the demo of parallel study as an unbalanced (subject in Test: 14's and 13's in Ref.) since bear v2.4.2 because it could cause error with previous version when the parallel was unbalanced when doing NCA. You can see the output file called Statistical_summaries.txt after running the demo dataset for more details. Therefore, I don't know if it is appropriate to use lm() to run unbalanced dataset as you did here. The reason to do that is only for my convenience when coding bear and testing it. The unbalanced dataset is quite special for an unbalanced, parallel BE study in bear. I got the bug information from a Greek user.

❝ Residuals:

❝ ALL 20 residuals are 0: no residual degrees of freedom!

❝ (over-specified!)

❝

❝ Coefficients: (1 not defined because of singularities)

❝ Estimate Std. Error t value Pr(>|t|)

❝ (Intercept) 7.3199 NA NA NA

❝ drug2 -0.0622 NA NA NA

❝ subj2 -0.5366 NA NA NA

❝ [...]

—
All the best,
-- Yung-jin Lee
bear v2.9.6:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

Complete thread:

Parallel bears meeting at random in infinity d_labes 2010-04-22 11:43
- Parallel bears meeting at random in infinity ElMaestro 2010-04-22 12:53
  - Parallel groups in bear - CIs d_labes 2010-04-22 14:00
    - Parallel groups in bear - CIs ElMaestro 2010-04-22 21:47
      - Parallel groups in bear - CIs d_labes 2010-04-23 09:09
    - Parallel groups in bear - CIs yjlee168 2010-04-25 23:29
- Parallel bears meeting at random in infinityyjlee168 2010-04-22 23:09
  - Modelling Parallel bears d_labes 2010-04-23 09:12
    - Modelling Parallel bears yjlee168 2010-04-23 21:14
      - Validating vs. WinNonlin... Helmut 2010-04-24 00:28
        
        Validating vs. WinNonlin... yjlee168 2010-04-24 19:36
        Validating vs. WinNonlin... yjlee168 2010-04-26 00:09
        
        Validating vs. WinNonlin... Helmut 2010-04-26 01:29
        
        WNL in replicate BE yjlee168 2010-04-26 08:59
        
        WNL in replicate BE Helmut 2010-04-26 16:15
      - Modelling Parallel bears yjlee168 2010-04-25 19:34
        
        Modelling Parallel bears ElMaestro 2010-04-25 20:40
        Dataset Helmut 2010-04-25 22:38
        
        Dataset yjlee168 2010-04-25 22:44
        
        Dataset Helmut 2010-04-26 01:13
        
        Dataset yjlee168 2010-04-26 08:16
        
        NCA → Statistical analysis for parallel study Helmut 2010-04-26 13:12
        
        NCA → Statistical analysis for parallel study yjlee168 2010-04-26 18:43
        
        dilemma yjlee168 2010-04-26 08:41
        Equal variances d_labes 2010-04-26 09:04
        
        Equal variances yjlee168 2010-04-26 09:22
        
        GLM = Equal variances d_labes 2010-04-26 13:29
        
        GLM = Equal variances Helmut 2010-04-26 14:45
        
        I'm a believer d_labes 2010-04-26 15:58
        
        I'm a believer Helmut 2010-04-26 16:31
        
        Equal variances Helmut 2010-04-26 12:55
        
        gls() for unequal variances? d_labes 2010-04-26 16:36
        
        gls() for unequal variances? Helmut 2010-04-26 17:00
        Sims Helmut 2010-04-27 01:36
        
        Sandwich - Simsalabim d_labes 2010-04-28 10:58
        
        Sandwich - Simsalabim Helmut 2010-04-28 14:19
        parametrization of R function rlnorm martin 2010-05-02 18:22
        
        Mean of log-normal d_labes 2010-05-03 16:22
        parametrization of R function rlnorm ElMaestro 2013-07-26 21:42
        
        Martin‽ Helmut 2013-07-28 02:01