Bioequivalence and Bioavailability Forum

Dear D. Labes,

as the maintainer of the PK package I guess I need to say something here.

The output Helmut got was created with Version 1.01 of our package. Since then substantial improvements to the package have been made which (among other things) has led to a different output format being used.

In addition Versions of the package > 1.01 by default also compute the standard error of the AUC when using the auc function. As the example only contains data of one subject this variability is zero.

Using the function call without specifying the method means that a bootstrap interval will be computed which, due to the lack of variability, results in the error. Specifying the methods "t" or "z", however, gives the point estimate but a SE of zero and no confidence interval.

Best,

Jack