TTT method for lambda_z estimation [🇷 for BE/BA]

posted by yjlee168 Homepage – Kaohsiung, Taiwan, 2008-09-30 22:28 (6460 d 20:24 ago) – Posting: # 2453
Views: 89,300

Dear DLabes,

useR! <-- this is marvelous. I really like it very much.

❝ But I think your implementation is the TTT rule as invented: Take all points after 2 x tmax for estimating lambdaZ. Am I right?


Yes. We follow your suggestion to implement TTT method.

❝ Thus my suggestion is to restrict the maximum number of time points to use for lambdaZ estimation to the TTT range and in that range apply the search for points with adjR2 or whatever fit criterion you wish to apply.


You're absolutely right. Question is how we are going to set the maximum number of time points? How to define a reasonable number of points? If there is a acceptable number, your suggestion should be easy to implement. It will sound like the combination way of the TTT method with adj. R2 (Ace's proposed algorithm and WinNonlin method).
—
All the best,
-- Yung-jin Lee
bear v2.9.6:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here
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