Bioequivalence and Bioavailability Forum

Occupancy, Half Value Duration, Plateau Time in Phoenix/WinNonlin 8 [🇷 for BE/BA]

posted by Astea – Russia, 2017-10-31 02:12 (3143 d 09:18 ago) – Posting: # 17957
Views: 31,474

Dear Helmut!

Thank you for the detailed explanation!

Now everything became clear excepting directly intersections. If the calculation of TimeLow and TimeDur are based on the difference between intersections, why are they not included into output or elsewhere? Of course, the structure of the curve should be more complicated and there could be several intersections...

So, how to get pointed values 0.595 to 8.386 or 0.595 to 8.257 not by hand, brain, R, Excel but by Phoenix?

For a single peak chart I come up with insane ideas of initial data manipulation namely truncating or reflecting the curve.

For example, with the mentioned dataset:

1. cutting data from 0 to C_max we'll get TimeLow=T_50%^early =0.595056.
   
2. cutting data from C_max to T_last and moving graph to zero we'll get T_50%^late equal to TimeHigh+T_max= 8.386133 or 8.256799 depending on the selected trapezoidal method.
   
3. reflecting the decreasing part of the curve (that is for C_t>C_max C_t->2C_max-C_t) and choosing Lower=0.5C_max, Upper=1.5 C_max, we'll get together linear TimeLow=T_50%^early=0.595056 and TimeLow+TimeDur=T_50%^late=8.386133.

Looks mad, can it be made easier?

Complete thread:

• Calculation of time above MIC Aceto81 2008-06-26 16:31 
  • Calculation of time above MIC Helmut 2008-06-26 18:58
    • Calculation of time above MIC Aceto81 2008-06-26 21:50
      • Calculation of time above MIC Helmut 2008-06-27 00:18
      • Calculation of time above MIC Helmut 2008-06-29 02:24
        • Calculation of time above MIC Aceto81 2008-06-30 15:50
          • Therapeutic Occupancy Time / MEC Helmut 2008-06-30 16:45
    • Time above MIC (WinNonlin 5.2.1) Helmut 2008-08-08 20:38
      • Time above MIC (WinNonlin 5.2.1) Aceto81 2008-08-12 09:56
        • Time above MIC (WinNonlin 5.2.1) Helmut 2008-08-12 12:32
          • Time above MIC (R function) Aceto81 2008-08-13 11:19
            • Time above MIC (R function) Helmut 2008-08-13 13:18
              • Time above MIC (R function) Aceto81 2008-08-13 15:35
          • Phoenix-WinNonlin 6.0 released 29 May 2009 SDavis 2009-06-04 10:55
            • Phoenix-WinNonlin 6.0 Helmut 2009-06-04 11:57
              • Phoenix-WinNonlin 6.0 - introductory webinars SDavis 2009-06-04 18:50
                • Phoenix-WinNonlin 6.0 - introductory webinars Helmut 2009-06-04 23:40
      • TimeLow Astea 2017-10-28 22:15
        • PHX/WNL 8.0 vs. previous releases Helmut 2017-10-28 23:20
          • PHX/WNL 8.0 vs. previous releases Astea 2017-10-28 23:49
        • Occupancy, Half Value Duration, Plateau Time in Phoenix/WinNonlin 8 Helmut 2017-10-30 13:18
          • Occupancy, Half Value Duration, Plateau Time in Phoenix/WinNonlin 8Astea 2017-10-31 01:12
            • Intersections Helmut 2017-10-31 12:32
              • nobody needs it... Astea 2017-10-31 18:24