Bioequivalence and Bioavailability Forum

adjusted means (aka LSMs) [Study Per­for­mance]

posted by khaoula – Algeria, 2014-08-25 23:41 (3967 d 12:24 ago) – Posting: # 13430
Views: 18,214

Hi Helmut,
thank you very much for your answer, I'm very sorry to reply so late, at first I did not have internet, then I fell very ill.
so I was wrong, I thought that after I sent the new results you answered me and GMR = 1.21 again !!! so now it's OK there is no problem between kinetica and unbalanced cross over !!!

two problems only:

1. calculation of CV (but it's not my job to find problem of software).
   
2. calculation of sequence effect: I read the book "Design and Analysis of Bioavailability and Bioequivalence Studies "(Shein-Chung Chow) Chapter 3 Statistical Inferences for Effects from a Standard 2*2 Crossover Design, I understood how to calculate the differents effects applying student test and Analysis of Variance :D

can I sent to you tne result of AUCs and you recalculate them with Phoenix/WinNonlin6.3? ( to confirm the miscalculation of sequence effect)?
thank you very much I am very happy to have met you, you help me a lot !!!!!

Complete thread:

• randomization khaoula 2014-06-06 14:04 
  • Imbalanced cross-overs Helmut 2014-06-06 14:47
    • Imbalanced cross-overs khaoula 2014-06-06 16:03
      • CV 0.03%? Helmut 2014-06-07 13:52
      • Imbalanced cross-overs jag009 2014-06-09 15:36
        • Imbalanced cross-overs khaoula 2014-06-09 22:07
          • Bag full of bugs Helmut 2014-06-10 00:37
            • Randomisation? ElMaestro 2014-06-10 01:00
              • Randomisation? Helmut 2014-06-10 14:53
                • Randomisation? khaoula 2014-06-11 00:17
                  • Problems resolved? Helmut 2014-06-11 02:01
                    • Problems resolved? khaoula 2014-07-24 13:36
                      • corrected data in PHX/WNL Helmut 2014-07-27 01:37
          • Which version of Kinetica? Helmut 2014-06-11 19:51
            • Which version of Kinetica? khaoula 2014-06-12 00:41
            • Which version of Kinetica? khaoula 2014-07-25 00:49
              • adjusted means (aka LSMs) Helmut 2014-07-27 02:23
                • adjusted means (aka LSMs)khaoula 2014-08-25 21:41