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RegisterSnafued! WTF! &%$@! [Study Performance]
Hi Ohlbe & Helmut,
Not a joke. The reply from the project manager:
Subject 143 – the 3.5 hour sample should not have been collected due to the delay in resticks of 41 minutes. Unfortunately, both were collected, shipped. I have reached out to PK group for input regarding this.
Restick = Difficulty in drawing blood. WTF for 41 mins. How many holes did they poke? I don't know. The subject should've been dropped out since it is inhuman to poke so many holes (it hurts!).
P.S. Helmut,
From our previous discussion, you wrote:
I don't think you can make interpolation to obtain the concentration at the desire time right (example: interpolate 4 hr concentration from 3.5 hr and 4.25 hr concentration)? I thought you have to use the time point as is?
Thanks
John
Not a joke. The reply from the project manager:
Subject 143 – the 3.5 hour sample should not have been collected due to the delay in resticks of 41 minutes. Unfortunately, both were collected, shipped. I have reached out to PK group for input regarding this.
Restick = Difficulty in drawing blood. WTF for 41 mins. How many holes did they poke? I don't know. The subject should've been dropped out since it is inhuman to poke so many holes (it hurts!).
P.S. Helmut,
From our previous discussion, you wrote:
❝ BTW, if you ask Phoenix/WinNonlin for partial AUCs (and sampling wasn’t performed exactly at the cut-off time point) an interpolation between two adjacent time points (before/after) is used; linear if C2 ≥ C1 and log/linear if C2 < C1. Makes sense, IMHO.
I don't think you can make interpolation to obtain the concentration at the desire time right (example: interpolate 4 hr concentration from 3.5 hr and 4.25 hr concentration)? I thought you have to use the time point as is?
Thanks
John
Complete thread:
- Boneheads! jag009 2013-09-09 21:12
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- WTF ? Ohlbe 2013-09-09 21:26
- Snafued! Helmut 2013-09-09 21:55
- Snafued! WTF! &%$@!jag009 2013-09-10 16:11
- pAUCs Helmut 2013-09-11 21:01
- pAUCs - the SEQUEL jag009 2013-09-12 20:48
- A Nightmare on Elm Street Helmut 2013-09-13 00:55
- A Nightmare on Elm Street jag009 2013-09-13 15:26
- A Nightmare on Elm Street Helmut 2013-09-13 16:00
- A Nightmare on Elm Street jag009 2013-09-13 19:57
- A Nightmare on Elm Street Helmut 2013-09-13 16:00
- A Nightmare on Elm Street jag009 2013-09-13 15:26
- A Nightmare on Elm Street Helmut 2013-09-13 00:55
- pAUCs - the SEQUEL jag009 2013-09-12 20:48
- pAUCs Helmut 2013-09-11 21:01
- Snafued! WTF! &%$@!jag009 2013-09-10 16:11
- WTF ? jag009 2013-09-10 16:13
- Snafued! Helmut 2013-09-09 21:55
- WTF ? Ohlbe 2013-09-09 21:26
Ing. Helmut Schütz