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RegisterBlood sample collection procedure [Study Performance]
posted by Helmut 
– Vienna, Austria, 2013-08-17 16:49 (4342 d 22:26 ago) – Posting: # 11298
Views: 6,204
Hi KR,
whatever you do, as long as you stick to the same procedure throughout the entire study there will be no impact on its results. Time is the independent variable in PK and – leaving some sophisticated PopPK models aside – assumed to be free of error. Therefore, it is essential to record the actual time points as exactly as possible.
There is not right or wrong. Following your example (dosing at 7:00, scheduled sample at 8:00) most people start sampling at 8:00 and record the end of sampling. BTW, some sites equipped with a barcode system connected to e.g., ClinBase™ have a time resolution of four [sic] seconds. A little bit over the top, IMHO.
P.S.: Any particular reason why you posted in the Regulatives / Guidelines-category?
whatever you do, as long as you stick to the same procedure throughout the entire study there will be no impact on its results. Time is the independent variable in PK and – leaving some sophisticated PopPK models aside – assumed to be free of error. Therefore, it is essential to record the actual time points as exactly as possible.
❝ Which is the right practice in the industry ?
There is not right or wrong. Following your example (dosing at 7:00, scheduled sample at 8:00) most people start sampling at 8:00 and record the end of sampling. BTW, some sites equipped with a barcode system connected to e.g., ClinBase™ have a time resolution of four [sic] seconds. A little bit over the top, IMHO.
P.S.: Any particular reason why you posted in the Regulatives / Guidelines-category?
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Blood sample collection procedure KR 2013-08-17 12:07
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Blood sample collection procedureHelmut 2013-08-17 14:49
- Blood sample collection procedure KR 2013-08-17 19:41
- Blood sample collection procedure Dr_Dan 2013-08-19 10:54
- Start, end, mean? Helmut 2013-08-19 11:19
- Start, end, mean? Dr_Dan 2013-08-19 11:31
- At the end, finally Helmut 2013-08-19 11:34
- At the end, finally KR 2013-08-20 08:33
- At the end, finally Helmut 2013-08-19 11:34
- Start, end, mean? Dr_Dan 2013-08-19 11:31
- Start, end, mean? Helmut 2013-08-19 11:19
- Blood sample collection procedure Dr_Dan 2013-08-19 10:54
- Blood sample collection procedure KR 2013-08-17 19:41
- Blood sample collection procedureHelmut 2013-08-17 14:49
Ing. Helmut Schütz