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RegisterRapid dissolution paradox [Dissolution / BCS / IVIVC]
Greetings!
I have been facing a paradox with a specific solid dosage formula with rapid dissolution rate. When conducting the dissolution test at three conventional pH the %release of the test product at 4.5 pH lowers upon reaching the max %release in 5 mins and then reaches a plateau. This does not happen for the RLD at the same pH and the performance for both product at all remaining pH is similar.
I have faced this before with rapid dissolution products but i would really like to have a scientific explanation on this.
Any ideas?
Thank you
Edit: Category changed; see also this post #1. [Helmut]
I have been facing a paradox with a specific solid dosage formula with rapid dissolution rate. When conducting the dissolution test at three conventional pH the %release of the test product at 4.5 pH lowers upon reaching the max %release in 5 mins and then reaches a plateau. This does not happen for the RLD at the same pH and the performance for both product at all remaining pH is similar.
I have faced this before with rapid dissolution products but i would really like to have a scientific explanation on this.
Any ideas?
Thank you
Edit: Category changed; see also this post #1. [Helmut]
Complete thread:
- Rapid dissolution paradoxMelkor 2018-06-03 11:02
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Ing. Helmut Schütz