Bioequivalence and Bioavailability Forum

Marzo / Balant formula for parallel groups [Power / Sample Size]

posted by d_labes  – Berlin, Germany, 2013-02-04 09:44 (4534 d 22:10 ago) – Posting: # 9955
Views: 13,413

Hi kumar

❝ Can we give same justification for Parallel design.

Quite simply: No.
The parallel design has different design characteristics (degrees of freedom, design constant ...). Thus an analogous formula for that design must have a different numeric factor.
Figure out it by yourself if you feel the need (using the "large sample" formulas given in Julious). This should be not such hard for you as Statistician .

Just to cite myself: "In the current modern times there is no need for such formulas and they shouldn't be used any longer."

Complete thread:

• Significance The Outlaw Torn 2012-11-20 07:56 
  • Significance ElMaestro 2012-11-20 08:17
    • Significance The Outlaw Torn 2012-11-20 08:55
      • Quality vs. Clinical ElMaestro 2012-11-20 09:04
  • Sample size? Helmut 2012-11-20 20:10
    • Sample size? The Outlaw Torn 2012-11-21 07:52
    • Sample size? The Outlaw Torn 2012-11-22 10:55
      • Sample size, ratio, CV ↔ power Helmut 2012-11-22 13:35
        • Sample size, ratio, CV ↔ power The Outlaw Torn 2012-11-23 14:47
        • Sample size, ratio, CV ↔ power BEQool 2025-01-31 13:12
          • TOST != treatment effect mittyri 2025-02-20 13:13
          • Sample size, ratio, CV ↔ power zizou 2025-02-21 13:40
            • Not vice versa mittyri 2025-02-22 21:08
              • Not vice versa? zizou 2025-02-24 11:02
                • Not vice versa? mittyri 2025-02-25 06:12
  • Sample size calculation using Marzo and Balant method kumarnaidu 2013-01-31 07:48
    • Marzo / Balant formula d_labes 2013-01-31 10:05
      • Marzo / Balant formula kumarnaidu 2013-01-31 10:54
        • Marzo / Balant formula kumarnaidu 2013-02-04 05:48
          • Marzo / Balant formula for parallel groupsd_labes 2013-02-04 08:44