least square mean calculation [General Sta­tis­tics]

posted by bvoggu – 2010-08-18 09:49 (5774 d 05:17 ago) – Posting: # 5801
Views: 12,296

Dear all
My name is Bharat kumar (Trainee in pharmacokinetics dept.)
In our company, calculations of least square mean were done according to SAS only.
But i want to learn all those manually in excel.

Up to my knowledge... LSM will be calculated by doing average of parameter of one treatment in period 1 and average of same in period 2, followed by dividing the sum of both averages by 2 (2 in case of two periods, right?).
My questions are:
  1. While doing calculations with same formula, i am getting correct values for AUCt, Cmax but for AUCinf i am getting different values.
    Anybody will help me about this issue???
  2. what is the formula for calculation of standard error of difference?
  3. Please suggest me a book especially for statistical part of PK?
—
Regards,
Bharat

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