Bioequivalence and Bioavailability Forum

Dear Mr. Kr. Pavidus/Members,
Thank You very much for suggesting the use of ███████. But, I would be very much pleased if you can provide me any literature data on this? i.e., Are there any associated drug interactions with such a combination? In order to proceed with further studies, is it really necessary the use of an antiemetic in BA/BE study of donepezil SR vs IR tablets. If so, Can anyone provide me the literature data on such studies?

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With regard to the previous conversation on the use of ███████ as antiemetic to avoid Nausea and vomiting upon donepezil administration, I still had a doubt regarding the choice of antiemetic.
Literature data reveal that ███████ or promethazine can be used to avoid nausea and vomiting assosiated with rivastigmine as rivastigmine is metabolised by sulfate conjugation. Hence less prone to drug interactions. But Donepezil is metabolised by CYP 2D6 (minor), CYP 3A4 and CYP 1A2, hence making it a tedious job in choosing the right antiemetic. Is it appropriate to use ███████ prior to donepezil to prevent nausea and vomiting? Are there any studies reported using such a combination? Orelse Can anyone suggest me the safest antiemetic that can be administered to decrease the subject dropout rate?


Awaiting your reply.


Thanking You in anticipation
Regards,
Chaitanya.G

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Edit: Later post merged to this one. You can edit your posts within 24 hours; no need to open a new one. [Helmut]

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Edit: Deleted information considered proprietary by Pavidus’ employer (2010-12-08). [Helmut]